Adaptation to climate change is a priority for Guatemala and has been included in its Nationally Determined Contribution (NDC) as part of its response and commitment to the Paris Agreement. In a context of increasing adaptation needs, the Government of Guatemala developed a process to identify priority adaptation measures, supported through its engagement in the NDC Partnership. Led by the Ministry of Environment and Natural Resources (MARN) in collaboration with the International Union for Conservation of Nature (IUCN) and the World Bank, with financial support from the NDC Support Facility, adaptation measures in four sectors were considered: agriculture, livestock and food security; coastal marine areas; forests, ecosystems and protected areas; and disaster risk management. The process resulted in the identification of priority adaptation measures that are cost-efficient and which could generate important results in reducing vulnerability in the short- and medium-term. To facilitate the implementation and monitoring of the identified priority adaptation measures a roadmap was prepared, including for each measure, specific activities, institutions, indicators and possible sources of finance. The identification of priority adaptation measures aimed to inform the process to review and update Guatemala’s NDC.